Thr200
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Home > Phosphorylation Site Page: > Thr200  -  TGFBR1 (human)

Site Information
LPLLVQRtIARtIVL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4325704

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 1 ) , [32P] bio-synthetic labeling ( 2 ) , flow cytometry ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , phosphopeptide mapping ( 2 ) , western blotting ( 1 )
Disease tissue studied:
leukemia ( 1 ) , T cell leukemia ( 1 )
Relevant cell line - cell type - tissue:
CD4+ (T lymphocyte) ( 1 ) , Jurkat (T lymphocyte) ( 1 ) , R-1B ('epithelial, lung') ( 2 )

Upstream Regulation
Regulatory protein:
TGFBR2 (human) ( 1 )
Putative in vivo kinases:
PKCA (human) ( 1 )
Kinases, in vitro:
PKCA (human) ( 1 ) , TGFBR2 (human) ( 1 )
Treatments:
TGF-beta ( 2 )

Downstream Regulation
Effects of modification on TGFBR1:
enzymatic activity, induced ( 1 , 2 ) , molecular association, regulation ( 1 ) , phosphorylation ( 2 )
Effects of modification on biological processes:
cell differentiation, induced ( 1 ) , signaling pathway regulation ( 1 )
Inhibit interaction with:
FKBP12 (human) ( 1 )

References 

1

Meisel M, et al. (2013) The kinase PKCα selectively upregulates interleukin-17A during Th17 cell immune responses. Immunity 38, 41-52
23290522   Curated Info

2

Wieser R, Wrana JL, Massagué J (1995) GS domain mutations that constitutively activate T beta R-I, the downstream signaling component in the TGF-beta receptor complex. EMBO J 14, 2199-208
7774578   Curated Info