Ser1159
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.6.0.2
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser1159  -  Huntingtin (mouse)

Site Information
LTNPPSLsPIRRKGK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 465621

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 2 ) , 'brain, hippocampus, dentate gyrus' ( 2 ) , 'neuron, cortical'-brain ( 1 , 3 ) , 'neuron, hippocampal'-brain ( 1 ) , neuron-'brain, hippocampus' ( 2 )

Upstream Regulation
Regulatory protein:
CDK5R1 (human) ( 1 )
Putative in vivo kinases:
CDK5 (mouse) ( 1 )
Treatments:
corticosterone ( 1 ) , dexamethasone ( 1 ) , ionizing_radiation ( 3 ) , Irinotecan ( 3 ) , seliciclib ( 1 , 3 )

Downstream Regulation
Effects of modification on Huntingtin:
intracellular localization ( 1 )
Effects of modification on biological processes:
apoptosis, inhibited ( 3 ) , cell differentiation, inhibited ( 1 , 2 ) , cell growth, inhibited ( 1 , 2 ) , exocytosis, inhibited ( 2 ) , transcription, inhibited ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
depression ( 1 , 2 )

References 

1

Agasse F, et al. (2020) Chronic Corticosterone Elevation Suppresses Adult Hippocampal Neurogenesis by Hyperphosphorylating Huntingtin. Cell Rep 32, 107865
32640230   Curated Info

2

Ben M'barek K, et al. (2013) Huntingtin mediates anxiety/depression-related behaviors and hippocampal neurogenesis. J Neurosci 33, 8608-20
23678106   Curated Info

3

Anne SL, Saudou F, Humbert S (2007) Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons. J Neurosci 27, 7318-28
17611284   Curated Info