Ser1179
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.6.0.2
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser1179  -  Huntingtin (mouse)

Site Information
EQASTPMsPKKVGEA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 465620

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 5 ) , mass spectrometry ( 3 , 4 , 6 , 7 ) , mutation of modification site ( 1 , 5 ) , phospho-antibody ( 1 , 5 , 8 ) , western blotting ( 1 , 5 )
Relevant cell line - cell type - tissue:
'3T3-L1, differentiated' (adipocyte) ( 3 , 4 ) , 'brain, cerebral cortex' ( 5 ) , 'brain, hippocampus, dentate gyrus' ( 5 ) , 'neuron, cortical'-brain ( 1 , 8 ) , 'neuron, hippocampal'-brain ( 1 ) , brain ( 6 ) , neuron-'brain, hippocampus' ( 5 ) , testis ( 7 )

Upstream Regulation
Regulatory protein:
CDK5R1 (human) ( 1 )
Putative in vivo kinases:
CDK5 (mouse) ( 1 )
Treatments:
corticosterone ( 1 ) , dexamethasone ( 1 ) , insulin ( 4 ) , ionizing_radiation ( 8 ) , Irinotecan ( 8 ) , seliciclib ( 1 , 8 )

Downstream Regulation
Effects of modification on Huntingtin:
intracellular localization ( 1 )
Effects of modification on biological processes:
apoptosis, inhibited ( 8 ) , cell differentiation, inhibited ( 1 , 5 ) , cell growth, inhibited ( 1 , 5 ) , exocytosis, inhibited ( 5 ) , transcription, inhibited ( 5 )

Disease / Diagnostics Relevance
Relevant diseases:
depression ( 1 , 5 )

References 

1

Agasse F, et al. (2020) Chronic Corticosterone Elevation Suppresses Adult Hippocampal Neurogenesis by Hyperphosphorylating Huntingtin. Cell Rep 32, 107865
32640230   Curated Info

2

Sacco F, et al. (2016) Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion. Nat Commun 7, 13250
27841257   Curated Info

3

Parker BL, et al. (2015) Targeted phosphoproteomics of insulin signaling using data-independent acquisition mass spectrometry. Sci Signal 8, rs6
26060331   Curated Info

4

Humphrey SJ, et al. (2013) Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2. Cell Metab 17, 1009-20
23684622   Curated Info

5

Ben M'barek K, et al. (2013) Huntingtin mediates anxiety/depression-related behaviors and hippocampal neurogenesis. J Neurosci 33, 8608-20
23678106   Curated Info

6

Trinidad JC, et al. (2012) Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics 11, 215-29
22645316   Curated Info

7

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

8

Anne SL, Saudou F, Humbert S (2007) Phosphorylation of huntingtin by cyclin-dependent kinase 5 is induced by DNA damage and regulates wild-type and mutant huntingtin toxicity in neurons. J Neurosci 27, 7318-28
17611284   Curated Info