Tyr829
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Home > Phosphorylation Site Page: > Tyr829  -  TIAM1 (mouse)

Site Information
PQPEEDIyELLYKEI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 465610

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
'neuron, cortical'-brain ( 1 , 2 ) , COS (fibroblast) ( 2 ) , HEK293T (epithelial) ( 1 )

Upstream Regulation
Kinases, in vitro:
TrkB (mouse) ( 2 )
Treatments:
BDNF ( 1 )

Downstream Regulation
Effects of modification on biological processes:
cytoskeletal reorganization ( 2 )

References 

1

Lai KO, et al. (2012) TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory. Nat Neurosci 15, 1506-15
23064382   Curated Info

2

Miyamoto Y, et al. (2006) TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology. Proc Natl Acad Sci U S A 103, 10444-9
16801538   Curated Info

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