Ser171
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Home > Phosphorylation Site Page: > Ser171  -  ER-alpha (mouse)

Site Information
NGRERLSsSNEKGNM   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448102

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 )
Disease tissue studied:
endometrial cancer ( 2 ) , endometrial adenocarcinoma ( 2 )
Relevant cell line - cell type - tissue:
'stem, mesenchymal' ( 1 ) , bone marrow ( 1 ) , epithelial ( 3 ) , Ishikawa (endometrial) ( 2 ) , uterus ( 2 )

Upstream Regulation
Regulatory protein:
Akt1 (mouse) ( 2 ) , PTEN (mouse) ( 2 )
Putative in vivo kinases:
p70S6K (mouse) ( 1 )
Treatments:
EGF ( 3 ) , estradiol ( 3 ) , faslodex ( 2 )

Downstream Regulation
Effects of modification on ER-alpha:
activity, induced ( 2 )
Effects of modification on biological processes:
cell differentiation, induced ( 1 ) , transcription, induced ( 1 , 2 )

Disease / Diagnostics Relevance
Relevant diseases:
endometrial cancer ( 2 )

References 

1

Dai Q, et al. (2017) mTOR/Raptor signaling is critical for skeletogenesis in mice through the regulation of Runx2 expression. Cell Death Differ 24, 1886-1899
28686577   Curated Info

2

Vilgelm A, et al. (2006) Akt-mediated phosphorylation and activation of estrogen receptor alpha is required for endometrial neoplastic transformation in Pten+/- mice. Cancer Res 66, 3375-80
16585156   Curated Info

3

Miyagawa S, Katsu Y, Watanabe H, Iguchi T (2004) Estrogen-independent activation of erbBs signaling and estrogen receptor alpha in the mouse vagina exposed neonatally to diethylstilbestrol. Oncogene 23, 340-9
14647453   Curated Info

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