Ser122
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Home > Phosphorylation Site Page: > Ser122  -  ER-alpha (mouse)

Site Information
LHPPPQLsPFLHPHG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448101

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 4 ) , mutation of modification site ( 4 ) , peptide sequencing ( 4 ) , phospho-antibody ( 2 , 3 ) , phosphopeptide mapping ( 4 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:
COS (fibroblast) ( 4 ) , epithelial ( 3 ) , MEF (fibroblast) ( 2 )

Upstream Regulation
Regulatory protein:
BRCA1 (mouse) ( 2 )
Treatments:
AG1478 ( 3 ) , AG825 ( 3 ) , EGF ( 3 ) , estradiol ( 3 )

Downstream Regulation
Effects of modification on biological processes:
transcription, altered ( 4 )

References 

1

Horkeby K, et al. (2022) Phosphorylation of S122 in ERĪ± is important for the skeletal response to estrogen treatment in male mice. Sci Rep 12, 22449
36575297   Curated Info

2

Kim SS, et al. (2009) Impaired skin and mammary gland development and increased gamma-irradiation-induced tumorigenesis in mice carrying a mutation of S1152-ATM phosphorylation site in Brca1. Cancer Res 69, 9291-300
19996295   Curated Info

3

Miyagawa S, Katsu Y, Watanabe H, Iguchi T (2004) Estrogen-independent activation of erbBs signaling and estrogen receptor alpha in the mouse vagina exposed neonatally to diethylstilbestrol. Oncogene 23, 340-9
14647453   Curated Info

4

Lahooti H, et al. (1995) Identification of phosphorylation sites in the mouse oestrogen receptor. J Steroid Biochem Mol Biol 55, 305-13
8541227   Curated Info