Tyr881
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Home > Phosphorylation Site Page: > Tyr881  -  Pyk2 (mouse)

Site Information
DRTDDLVyHNVMTLV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447958

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 1 , 2 , 3 , 4 , 5 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
AB.1 (T lymphocyte) ( 1 ) , NMuMG (epithelial) ( 5 ) , osteoclast ( 3 ) , PC-12 (chromaffin) ( 2 ) , T lymphocyte-blood ( 4 )

Upstream Regulation
Regulatory protein:
VAV1 (mouse) ( 4 )
Putative in vivo kinases:
Src (mouse) ( 2 )
Treatments:
1-butanol ( 2 ) , anti-CD3 ( 1 , 4 ) , anti-ITGAL ( 4 ) , EGF ( 2 ) , fibronectin ( 4 ) , H2O2 ( 2 ) , ionomycin ( 1 ) , low_cell_density ( 5 ) , PP2 ( 1 , 2 ) , PP3 ( 1 ) , t-butanol ( 2 ) , TGF-beta ( 5 )

References 

1

Lysechko TL, Cheung SM, Ostergaard HL (2010) Regulation of the tyrosine kinase Pyk2 by calcium is through production of reactive oxygen species in cytotoxic T lymphocytes. J Biol Chem 285, 31174-84
20688918   Curated Info

2

Banno Y, et al. (2005) Implication of phospholipase D2 in oxidant-induced phosphoinositide 3-kinase signaling via Pyk2 activation in PC12 cells. J Biol Chem 280, 16319-24
15705590   Curated Info

3

Lakkakorpi PT, et al. (2003) PYK2 autophosphorylation, but not kinase activity, is necessary for adhesion-induced association with c-Src, osteoclast spreading, and bone resorption. J Biol Chem 278, 11502-12
12514172   Curated Info

4

Krawczyk C, et al. (2002) Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity 16, 331-43
11911819   Curated Info

5

Nakamura K, Yano H, Schaefer E, Sabe H (2001) Different modes and qualities of tyrosine phosphorylation of Fak and Pyk2 during epithelial-mesenchymal transdifferentiation and cell migration: analysis of specific phosphorylation events using site-directed antibodies. Oncogene 20, 2626-35
11420674   Curated Info