Ser488
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Home > Phosphorylation Site Page: > Ser488  -  HDAC5 (mouse)

Site Information
RPLSRtQsSPLPQSP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447996

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 4 , 5 ) , mutation of modification site ( 6 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
'brain, embryonic' ( 5 ) , C3H10T1/2 (fibroblast) ( 6 ) , COS (fibroblast) ( 6 ) , liver ( 4 ) , MEF (fibroblast) ( 2 ) , myocyte-heart ( 1 )

Upstream Regulation
Putative in vivo kinases:
CAMK2D (mouse) ( 1 )
Treatments:
caffeine ( 1 ) , glucagon ( 3 ) , KN-93 ( 1 ) , phenformin ( 3 ) , phenylephrine ( 1 )

Downstream Regulation
Effects of modification on HDAC5:
molecular association, regulation ( 6 )
Induce interaction with:
14-3-3 epsilon (human) ( 6 )
Inhibit interaction with:
MEF2C (mouse) ( 6 )

References 

1

Mishra S, et al. (2011) Location matters: clarifying the concept of nuclear and cytosolic CaMKII subtypes. Circ Res 109, 1354-62
21998325   Curated Info

2

Yu Y, et al. (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332, 1322-6
21659605   Curated Info

3

Mihaylova MM, et al. (2011) Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. Cell 145, 607-21
21565617   Curated Info

4

Possemato A (2009) CST Curation Set: 8043; Year: 2011; Biosample/Treatment: tissue, liver/AICAR; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST]
Curated Info

5

Possemato A (2008) CST Curation Set: 3818; Year: 2008; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser/Thr) PKD Substrate Antibody Cat#: 4381, PTMScan(R) Phospho-PKD Substrate Motif (LXRXXpS/pT) Immunoaffinity Beads Cat#: 1986
Curated Info

6

McKinsey TA, Zhang CL, Olson EN (2000) Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5. Proc Natl Acad Sci U S A 97, 14400-5
11114197   Curated Info