Ser276
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Home > Phosphorylation Site Page: > Ser276  -  AQP4 (rat)

Site Information
AAQQTkGsYMEVEDN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 465556

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 3 )
Relevant cell line - cell type - tissue:
'brain, brainstem' ( 1 ) , 'brain, cerebellum' ( 1 ) , 'brain, cerebral cortex' ( 1 ) , 'kidney, inner medulla' ( 2 ) , MDCK (epithelial) ( 3 ) , pancreas ( 1 ) , thymus ( 1 )

Upstream Regulation
Kinases, in vitro:
CK2A1 (human) ( 3 )

Downstream Regulation
Effects of modification on AQP4:
intracellular localization ( 3 ) , molecular association, regulation ( 3 ) , protein degradation ( 3 )
Induce interaction with:
AP3M1 (human) ( 3 )

References 

1

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

2

Hoffert JD, et al. (2007) An automated platform for analysis of phosphoproteomic datasets: application to kidney collecting duct phosphoproteins. J Proteome Res 6, 3501-8
17683130   Curated Info

3

Madrid R, et al. (2001) Polarized trafficking and surface expression of the AQP4 water channel are coordinated by serial and regulated interactions with different clathrin-adaptor complexes. EMBO J 20, 7008-21
11742978   Curated Info