Ser274
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Home > Phosphorylation Site Page: > Ser274  -  PXN (human)

Site Information
DELMAsLsDFkIQGL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 465490

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 4 ) , mutation of modification site ( 3 ) , western blotting ( 3 )
Disease tissue studied:
leukemia ( 3 ) , acute myelogenous leukemia ( 3 ) , lung cancer ( 1 , 4 ) , non-small cell lung cancer ( 4 ) , non-small cell lung adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 3 ) , liver ( 2 ) , ML-1 [Human leukemia] (myeloid) ( 3 ) , NCI-H1395 (pulmonary) ( 4 ) , NCI-H2030 (pulmonary) ( 4 ) , PC9 (pulmonary) ( 1 ) , PC9-IR (pulmonary) ( 1 )

Upstream Regulation
Putative in vivo kinases:
PAK2 (human) ( 3 )

Downstream Regulation
Effects of modification on PXN:
molecular association, regulation ( 3 )
Induce interaction with:
TACE (human) ( 3 )

References 

1

Tsai CF, et al. (2015) Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics. Nat Commun 6, 6622
25814448   Curated Info

2

Bian Y, et al. (2014) An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics 96, 253-62
24275569   Curated Info

3

Lee JH, et al. (2013) HIV Nef, Paxillin, and Pak1/2 Regulate Activation and Secretion of TACE/ADAM10 Proteases. Mol Cell 49, 668-79
23317503   Curated Info

4

Klammer M, et al. (2012) Phosphosignature predicts dasatinib response in non-small cell lung cancer. Mol Cell Proteomics 11, 651-68
22617229   Curated Info

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