Tyr1063
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Home > Phosphorylation Site Page: > Tyr1063  -  Ret (mouse)

Site Information
TWIENKLyGMSDPNW   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447625

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 , 2 , 4 ) , mutation of modification site ( 2 , 4 , 5 , 6 , 7 , 8 ) , phospho-antibody ( 1 , 2 , 3 , 4 , 7 , 8 ) , western blotting ( 1 )
Disease tissue studied:
gastric cancer ( 1 ) , gastric carcinoma ( 1 )
Relevant cell line - cell type - tissue:
'brain, cerebellum' ( 2 ) , 'neuron, cochlear' ( 4 ) , 'neuron, Purkinje'-'brain, cerebellum' ( 2 ) , 293 (epithelial) ( 7 ) , 3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout] ( 6 , 8 ) , AGS (gastric) ( 1 ) , colon ( 3 ) , COS (fibroblast) ( 8 ) , GCs (neuron) ( 2 ) , glial ( 2 ) , HEK293T (epithelial) ( 5 ) , N87 (gastric) ( 1 ) , Neuro-2a (neuron) ( 7 ) , PC-12 (chromaffin) ( 7 ) , stomach ( 1 )

Upstream Regulation
Regulatory protein:
ATOH1 (human) ( 1 ) , GAS1 (human) ( 1 )
Putative in vivo kinases:
Ret (mouse) ( 8 )
Treatments:
AzaC ( 1 ) , EGF ( 8 ) , GDNF ( 7 ) , pressure ( 3 ) , thioridazine hydrochloride ( 1 )

Downstream Regulation
Effects of modification on Ret:
enzymatic activity, induced ( 3 ) , molecular association, regulation ( 6 , 7 )
Effects of modification on biological processes:
cell growth, induced ( 2 ) , cytoskeletal reorganization ( 7 ) , transcription, induced ( 2 )
Induce interaction with:
DOK1 (mouse) ( 6 ) , DOK2 (mouse) ( 7 ) , DOK4 (mouse) ( 7 ) , DOK5 (mouse) ( 7 )

Disease / Diagnostics Relevance
Relevant diseases:
gastric carcinoma ( 1 )

References 

1

Zhong Q, et al. (2023) Loss of ATOH1 in Pit Cell Drives Stemness and Progression of Gastric Adenocarcinoma by Activating AKT/mTOR Signaling through GAS1. Adv Sci (Weinh), e2301977
37824217   Curated Info

2

Ohgami N, et al. (2021) Loss-of-function mutation of c-Ret causes cerebellar hypoplasia in mice with Hirschsprung disease and Down's syndrome. J Biol Chem 296, 100389
33561442   Curated Info

3

Fernández-Sánchez ME, et al. (2015) Mechanical induction of the tumorigenic β-catenin pathway by tumour growth pressure. Nature 523, 92-5
25970250   Curated Info

4

Ohgami N, et al. (2012) Partial impairment of c-Ret at tyrosine 1062 accelerates age-related hearing loss in mice. Neurobiol Aging 33, 626.e25-34
21612845   Curated Info

5

Iavarone C, et al. (2006) Activation of the Erk8 mitogen-activated protein (MAP) kinase by RET/PTC3, a constitutively active form of the RET proto-oncogene. J Biol Chem 281, 10567-76
16484222   Curated Info

6

Murakami H, et al. (2002) Role of Dok1 in cell signaling mediated by RET tyrosine kinase. J Biol Chem 277, 32781-90
12087092   Curated Info

7

Grimm J, et al. (2001) Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation. J Cell Biol 154, 345-54
11470823   Curated Info

8

Salvatore D, et al. (2000) Tyrosines 1015 and 1062 are in vivo autophosphorylation sites in ret and ret-derived oncoproteins. J Clin Endocrinol Metab 85, 3898-907
11061555   Curated Info

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