Ser15
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Home > Phosphorylation Site Page: > Ser15  -  MST2 (human)

Site Information
KSKLKkLsEDsLTkQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4272103

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 6 ) , mass spectrometry ( 1 , 2 , 3 , 7 , 8 , 9 , 10 , 11 , 12 ) , mass spectrometry (in vitro) ( 6 ) , mutation of modification site ( 6 )
Disease tissue studied:
HER2 positive breast cancer ( 1 ) , luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, surrounding tissue ( 1 ) , breast cancer, triple negative ( 1 ) , melanoma skin cancer ( 2 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 6 ) , A498 (renal) ( 10 ) , breast ( 1 ) , HeLa (cervical) ( 3 , 7 , 8 ) , HeLa S3 (cervical) ( 12 ) , HeLa_Meta (cervical) ( 9 ) , HeLa_Pro (cervical) ( 9 ) , HeLa_Telo (cervical) ( 9 ) , MDA-MB-435S (breast cell) ( 11 ) , MV4-11 (macrophage) ( 11 ) , WM239A (melanocyte) ( 2 )

Upstream Regulation
Putative in vivo kinases:
PLK1 (human) ( 6 )
Kinases, in vitro:
PLK1 (human) ( 6 )
Treatments:
MG132 ( 9 )

Downstream Regulation
Effects of modification on MST2:
molecular association, regulation ( 6 )
Effects of modification on biological processes:
cell cycle regulation ( 6 )
Inhibit interaction with:
NEK2 (human) ( 6 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Stuart SA, et al. (2015) A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics 14, 1599-615
25850435   Curated Info

3

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

4

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

5

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

6

Mardin BR, Agircan FG, Lange C, Schiebel E (2011) Plk1 controls the Nek2A-PP1γ antagonism in centrosome disjunction. Curr Biol 21, 1145-51
21723128   Curated Info

7

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

8

Hegemann B, et al. (2011) Systematic phosphorylation analysis of human mitotic protein complexes. Sci Signal 4, rs12
22067460   Curated Info

9

Dulla K, et al. (2010) Quantitative site-specific phosphorylation dynamics of human protein kinases during mitotic progression. Mol Cell Proteomics 9, 1167-81
20097925   Curated Info

10

Schreiber TB, et al. (2010) An integrated phosphoproteomics work flow reveals extensive network regulation in early lysophosphatidic acid signaling. Mol Cell Proteomics 9, 1047-62
20071362   Curated Info

11

Oppermann FS, et al. (2009) Large-scale proteomics analysis of the human kinome. Mol Cell Proteomics 8, 1751-64
19369195   Curated Info

12

Daub H, et al. (2008) Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell 31, 438-48
18691976   Curated Info