Ser410

Site Information
EkENQINsFGksVPG SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 4270855

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 3 , 4 , 5 , 7 , 8 , 9 , 10 ) , mass spectrometry (in vitro) ( 1 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 2 )
Disease tissue studied:	HER2 positive breast cancer ( 3 ) , luminal A breast cancer ( 3 ) , luminal B breast cancer ( 3 ) , breast cancer, surrounding tissue ( 3 ) , breast cancer, triple negative ( 3 ) , leukemia ( 2 ) , T cell leukemia ( 2 ) , melanoma skin cancer ( 4 )
Relevant cell line - cell type - tissue:	breast ( 3 ) , HCT116 (intestinal) ( 9 ) , HeLa (cervical) ( 5 ) , HeLa S3 (cervical) ( 10 ) , HeLa_Meta (cervical) ( 8 ) , HeLa_Pro (cervical) ( 8 ) , HeLa_Telo (cervical) ( 8 ) , Jurkat (T lymphocyte) ( 2 ) , K562 (erythroid) ( 7 ) , MDA-MB-435S (breast cell) ( 9 ) , WM239A (melanocyte) ( 4 )

Upstream Regulation
Treatments:	MG132 ( 8 ) , MG132_withdrawal ( 8 ) , pictilisib ( 2 ) , SCH772984 ( 2 )

References
1	Turunen SP, et al. (2019) FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis. Cell Death Differ 30903103 Curated Info
2	Nováková J, Talacko P, Novák P, Vališ K (2019) The MEK-ERK-MST1 Axis Potentiates the Activation of the Extrinsic Apoptotic Pathway during GDC-0941 Treatment in Jurkat T Cells. Cells 8 30795621 Curated Info
3	Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62 27251275 Curated Info
4	Stuart SA, et al. (2015) A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells. Mol Cell Proteomics 14, 1599-615 25850435 Curated Info
5	Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94 25159151 Curated Info
6	Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704 24719451 Curated Info
7	Zhou H, et al. (2013) Toward a comprehensive characterization of a human cancer cell phosphoproteome. J Proteome Res 12, 260-71 23186163 Curated Info
8	Dulla K, et al. (2010) Quantitative site-specific phosphorylation dynamics of human protein kinases during mitotic progression. Mol Cell Proteomics 9, 1167-81 20097925 Curated Info
9	Oppermann FS, et al. (2009) Large-scale proteomics analysis of the human kinome. Mol Cell Proteomics 8, 1751-64 19369195 Curated Info
10	Daub H, et al. (2008) Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell 31, 438-48 18691976 Curated Info