Tyr474
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Home > Phosphorylation Site Page: > Tyr474  -  RIPK2 (human)

Site Information
DLIMKEDyELVSTkP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4270705

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 , 3 , 5 ) , mass spectrometry ( 5 ) , mutation of modification site ( 1 , 3 , 5 ) , phospho-antibody ( 1 , 4 ) , western blotting ( 1 , 2 )
Disease tissue studied:
colorectal cancer ( 5 ) , colorectal carcinoma ( 5 ) , leukemia ( 1 ) , acute myelogenous leukemia ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 3 , 5 ) , BEAS-2B (epithelial) ( 4 ) , HEK293T (epithelial) ( 1 , 2 ) , HeLa (cervical) ( 1 ) , HT-29 (intestinal) ( 5 ) , macrophage-bone marrow ( 2 ) , MEF (fibroblast) ( 5 ) , RAW 264.7 (macrophage) ( 1 ) , THP1 (myeloid) ( 1 )

Upstream Regulation
Regulatory protein:
NOD2 (human) ( 2 , 5 )
Putative in vivo kinases:
FGR (human) ( 2 ) , RIPK2 (human) ( 1 , 2 )
Kinases, in vitro:
FGR (human) ( 2 ) , RIPK2 (human) ( 2 , 5 )
Treatments:
antibody ( 2 ) , bacterial infection ( 1 ) , BSA ( 2 ) , erlotinib ( 5 ) , Fas ( 4 ) , gefitinib ( 5 ) , MOD ( 5 ) , siRNA ( 5 )

Downstream Regulation
Effects of modification on RIPK2:
enzymatic activity, induced ( 2 , 5 ) , molecular association, regulation ( 3 , 5 ) , protein degradation ( 5 ) , ubiquitination ( 5 )
Effects of modification on biological processes:
signaling pathway regulation ( 1 , 2 ) , transcription, induced ( 1 )
Induce interaction with:
NOD1 (human) ( 3 ) , NOD2 (human) ( 5 )

Disease / Diagnostics Relevance
Relevant diseases:
Crohn disease ( 5 )

References 

1

Ellwanger K, et al. (2019) XIAP controls RIPK2 signaling by preventing its deposition in speck-like structures. Life Sci Alliance 2
31350258   Curated Info

2

Shehat MG, et al. (2019) RIP2 promotes FcγR-mediated reactive oxygen species production. J Biol Chem 294, 10365-10378
31113864   Curated Info

3

Mayle S, et al. (2014) Engagement of Nucleotide-binding Oligomerization Domain-containing Protein 1 (NOD1) by Receptor-interacting Protein 2 (RIP2) Is Insufficient for Signal Transduction. J Biol Chem 289, 22900-14
24958724   Curated Info

4

Rahman MA, et al. (2014) Receptor interacting protein-2 plays a critical role in human lung epithelial cells survival in response to fas-induced cell-death. PLoS One 9, e92731
24658576   Curated Info

5

Tigno-Aranjuez JT, Asara JM, Abbott DW (2010) Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses. Genes Dev 24, 2666-77
21123652   Curated Info

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