Tyr509
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Home > Phosphorylation Site Page: > Tyr509  -  PLCG1 (cow)

Site Information
NHEWYPHyFVLTSSK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 464036

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 2 )
Disease tissue studied:
lymphoma ( 2 ) , B cell lymphoma ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
anti-IgM ( 2 ) , EGF ( 1 )

Downstream Regulation
Effects of modification on PLCG1:
enzymatic activity, induced ( 2 )
Effects of modification on biological processes:
cell growth, altered ( 2 ) , cell motility, altered ( 2 ) , cytoskeletal reorganization ( 2 )
Induce interaction with:
PLCG1 (cow) ( 2 )

References 

1

Everett KL, et al. (2009) Characterization of Phospholipase C{gamma} Enzymes with Gain-of-Function Mutations. J Biol Chem 284, 23083-93
19531496   Curated Info

2

DeBell K, et al. (2007) Intramolecular regulation of phospholipase C-gamma1 by its C-terminal Src homology 2 domain. Mol Cell Biol 27, 854-63
17116690   Curated Info