Ser473
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Home > O-GlcNAc Site Page: > Ser473  -  Akt1 (rat)

Site Information
RPHFPQFsYSASGTA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4261200

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 ) , modification-specific antibody ( 2 ) , mutation of modification site ( 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 , 2 )
Disease tissue studied:
pancreatic cancer ( 2 ) , pancreatic carcinoma ( 2 )
Relevant cell line - cell type - tissue:
INS-1 (pancreatic) ( 2 ) , neuron-'brain, cerebral cortex' ( 1 )

Upstream Regulation
Treatments:
depolarization ( 1 ) , glucosamine ( 2 ) , IGF-1 ( 1 ) , LY294002 ( 1 ) , wortmannin ( 1 )

Downstream Regulation
Effects of modification on Akt1:
phosphorylation ( 2 )

References 

1

Song B, et al. (2010) Inhibitory phosphorylation of GSK-3 by CaMKII couples depolarization to neuronal survival. J Biol Chem 285, 41122-34
20841359   Curated Info

2

Kang ES, et al. (2008) O-GlcNAc modulation at Akt1 Ser473 correlates with apoptosis of murine pancreatic beta cells. Exp Cell Res 314, 2238-48
18570920   Curated Info