Ser1062
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Home > Phosphorylation Site Page: > Ser1062  -  SRC-3 (human)

Site Information
DQLHtLLsNtDAtGL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4252805

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , mass spectrometry ( 1 , 2 ) , mutation of modification site ( 1 , 3 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
gastric cancer ( 1 ) , gastric carcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
KIS (human) ( 1 ) , PKCZ (human) ( 3 )
Kinases, in vitro:
KIS (human) ( 1 )
Treatments:
bacterial infection ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on SRC-3:
molecular association, regulation ( 1 , 3 ) , protein stabilization ( 3 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , transcription, induced ( 1 )
Induce interaction with:
ATF-4 (human) ( 1 ) , DNA ( 1 )
Inhibit interaction with:
PSMA3 (human) ( 3 )

Disease / Diagnostics Relevance
Relevant diseases:
gastric cancer ( 1 )

References 

1

Feng X, et al. (2020) UHMK1 promotes gastric cancer progression through reprogramming nucleotide metabolism. EMBO J, e102541
31975428   Curated Info

2

Stokes M (2008) CST Curation Set: 4217; Year: 2008; Biosample/Treatment: tissue, heart/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

3

Yi P, et al. (2008) Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1. Mol Cell 29, 465-76
18313384   Curated Info