Thr1067
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Home > Phosphorylation Site Page: > Thr1067  -  SRC-3 (human)

Site Information
LLsNtDAtGLEEIDR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4252800

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
gastric cancer ( 1 ) , gastric carcinoma ( 1 )
Relevant cell line - cell type - tissue:
HeLa (cervical) ( 2 ) , HGC-27 (gastric) ( 1 ) , MGC-803 (gastric) ( 1 ) , SGC7901 (gastric) ( 1 )

Upstream Regulation
Putative in vivo kinases:
KIS (human) ( 1 ) , PKCZ (human) ( 2 )
Kinases, in vitro:
KIS (human) ( 1 )
Treatments:
bacterial infection ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on SRC-3:
molecular association, regulation ( 1 , 2 ) , protein stabilization ( 2 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , transcription, induced ( 1 )
Induce interaction with:
ATF-4 (human) ( 1 ) , DNA ( 1 )
Inhibit interaction with:
PSMA3 (human) ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
gastric cancer ( 1 )

References 

1

Feng X, et al. (2020) UHMK1 promotes gastric cancer progression through reprogramming nucleotide metabolism. EMBO J, e102541
31975428   Curated Info

2

Yi P, et al. (2008) Atypical protein kinase C regulates dual pathways for degradation of the oncogenic coactivator SRC-3/AIB1. Mol Cell 29, 465-76
18313384   Curated Info

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