Thr38
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Home > Phosphorylation Site Page: > Thr38  -  Ets-1 (mouse)

Site Information
CADVPLLtPSsKEMM   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447950

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 2 , 3 , 5 ) , phospho-antibody ( 2 , 3 , 4 , 5 ) , western blotting ( 2 , 3 , 4 , 5 )
Relevant cell line - cell type - tissue:
'B lymphocyte, precursor' ( 3 ) , 3T3 (fibroblast) ( 2 ) , B lymphocyte ( 3 ) , MDCK (epithelial) ( 5 ) , T lymphocyte-lymph node ( 4 ) , T lymphocyte-spleen ( 4 )

Upstream Regulation
Regulatory protein:
HRas (human) ( 5 ) , MEK1 (mouse) ( 2 ) , RAF1 (human) ( 5 )
Putative in vivo kinases:
ERK1 (human) ( 5 ) , ERK2 (human) ( 1 )
Kinases, in vitro:
ERK1 (human) ( 5 ) , ERK2 (mouse) ( 2 )
Treatments:
antibody ( 3 ) , HGF ( 5 ) , ionomycin ( 4 ) , phorbol_ester ( 4 ) , U0126 ( 3 , 5 )

Downstream Regulation
Effects of modification on Ets-1:
protein conformation ( 1 , 2 )
Effects of modification on biological processes:
transcription, induced ( 2 , 5 )
Induce interaction with:
CBP (mouse) ( 2 )

References 

1

Piserchio A, et al. (2017) Local destabilization, rigid body, and fuzzy docking facilitate the phosphorylation of the transcription factor Ets-1 by the mitogen-activated protein kinase ERK2. Proc Natl Acad Sci U S A 114, E6287-E6296
28716922   Curated Info

2

Nelson ML, et al. (2010) Ras signaling requires dynamic properties of Ets1 for phosphorylation-enhanced binding to coactivator CBP. Proc Natl Acad Sci U S A 107, 10026-31
20534573   Curated Info

3

Yasuda T, et al. (2008) Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion. Immunity 28, 499-508
18356083   Curated Info

4

Moisan J, et al. (2007) Ets-1 is a negative regulator of Th17 differentiation. J Exp Med 204, 2825-35
17967903   Curated Info

5

Paumelle R, et al. (2002) Hepatocyte growth factor/scatter factor activates the ETS1 transcription factor by a RAS-RAF-MEK-ERK signaling pathway. Oncogene 21, 2309-19
11948414   Curated Info