Ser306
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Home > Phosphorylation Site Page: > Ser306  -  GJA1 (rat)

Site Information
RNYNkQAsEQNWANy   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 465459

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 5 ) , mass spectrometry (in vitro) ( 3 ) , mutation of modification site ( 4 ) , phospho-antibody ( 4 ) , western blotting ( 4 )
Relevant cell line - cell type - tissue:
'brain, brainstem' ( 2 ) , 'brain, cerebellum' ( 2 ) , 'brain, cerebral cortex' ( 2 ) , heart ( 2 , 4 , 5 ) , HeLa (cervical) ( 4 ) , IEC-6 (epithelial) ( 1 ) , intestine ( 2 ) , lung ( 2 ) , spleen ( 2 ) , testis ( 2 )

Upstream Regulation
Kinases, in vitro:
CAMK2A (human) ( 3 )
Treatments:
ischemia ( 5 )

Downstream Regulation
Effects of modification on GJA1:
activity, induced ( 4 )

References 

1

Courcelles M, et al. (2013) Phosphoproteome dynamics reveal novel ERK1/2 MAP kinase substrates with broad spectrum of functions. Mol Syst Biol 9, 669
23712012   Curated Info

2

Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876
22673903   Curated Info

3

Huang RY, et al. (2011) Identification of CaMKII phosphorylation sites in Connexin43 by high-resolution mass spectrometry. J Proteome Res 10, 1098-109
21158428   Curated Info

4

Procida K, et al. (2009) Phosphorylation of connexin43 on serine 306 regulates electrical coupling. Heart Rhythm 6, 1632-8
19879542   Curated Info

5

Axelsen LN, et al. (2006) Identification of ischemia-regulated phosphorylation sites in connexin43: A possible target for the antiarrhythmic peptide analogue rotigaptide (ZP123). J Mol Cell Cardiol 40, 790-8
16678851   Curated Info