Ser297

Site Information
TGDRNNssCRNYNkQ SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 465458

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 2 , 5 ) , mass spectrometry (in vitro) ( 3 ) , mutation of modification site ( 1 , 4 )
Relevant cell line - cell type - tissue:	heart ( 2 , 5 ) , HeLa (cervical) ( 4 ) , oocyte ( 1 )

Upstream Regulation
Kinases, in vitro:	CAMK2A (human) ( 3 )
Treatments:	ischemia ( 5 ) , rotigaptide ( 5 )

References
1	Mitra SS, Xu J, Nicholson BJ (2012) Coregulation of Multiple Signaling Mechanisms in pp60v-Src-Induced Closure of Cx43 Gap Junction Channels. J Membr Biol 245, 495-506 22965738 Curated Info
2	Lundby A, et al. (2012) Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. Nat Commun 3, 876 22673903 Curated Info
3	Huang RY, et al. (2011) Identification of CaMKII phosphorylation sites in Connexin43 by high-resolution mass spectrometry. J Proteome Res 10, 1098-109 21158428 Curated Info
4	Procida K, et al. (2009) Phosphorylation of connexin43 on serine 306 regulates electrical coupling. Heart Rhythm 6, 1632-8 19879542 Curated Info
5	Axelsen LN, et al. (2006) Identification of ischemia-regulated phosphorylation sites in connexin43: A possible target for the antiarrhythmic peptide analogue rotigaptide (ZP123). J Mol Cell Cardiol 40, 790-8 16678851 Curated Info