Ser730
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Home > Phosphorylation Site Page: > Ser730  -  DNMT1 iso2 (human)

Site Information
DNIPEMPsPKKMHQG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 452655

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
HUVEC (endothelial) ( 1 ) , Jurkat (T lymphocyte) ( 2 )

Upstream Regulation
Putative in vivo kinases:
AMPKA1 (human) ( 1 )
Kinases, in vitro:
AMPKA1 (human) ( 1 )
Treatments:
acadesine ( 1 )

Downstream Regulation
Effects of modification on DNMT1 iso2:
activity, inhibited ( 1 ) , molecular association, regulation ( 1 ) , protein conformation ( 1 )
Induce interaction with:
RBBP7 (human) ( 1 )

References 

1

Marin TL, et al. (2017) AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1. Sci Signal 10
28143904   Curated Info

2

Zhou J (2009) CST Curation Set: 5896; Year: 2009; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: (K/R)XpSX(K/R)Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser) PKC Substrate Antibody Cat#: 2261, PTMScan(R) Phospho-PKC Substrate Motif (K/RXpSXK/R) Immunoaffinity Beads Cat#: 1985
Curated Info