Tyr145
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.4
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Tyr145  -  SLP76 (mouse)

Site Information
LVDDAADyEPPPSNN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448220

In vivo Characterization
Methods used to characterize site in vivo:
flow cytometry ( 5 ) , mutation of modification site ( 2 , 3 , 4 , 5 , 6 , 7 ) , phospho-antibody ( 1 , 3 , 4 , 5 , 6 ) , western blotting ( 1 , 3 , 4 , 5 , 6 )
Relevant cell line - cell type - tissue:
CD4+ (T lymphocyte) ( 1 ) , Jurkat (T lymphocyte) ( 3 , 5 , 7 ) , mast-bone marrow ( 6 ) , platelet-blood [SLP76 (mouse), homozygous knockout] ( 3 ) , renal ( 2 ) , thymocyte ( 4 )

Upstream Regulation
Regulatory protein:
SSU72 (mouse) ( 1 )
Treatments:
antibody ( 5 , 6 ) , convulxin ( 3 ) , vanadate ( 5 )

Downstream Regulation
Effects of modification on SLP76:
molecular association, regulation ( 6 ) , phosphorylation ( 4 )
Effects of modification on biological processes:
apoptosis, altered ( 4 ) , cell adhesion, altered ( 3 ) , cell differentiation, altered ( 4 ) , cytoskeletal reorganization ( 3 ) , transcription, altered ( 4 , 5 ) , transcription, induced ( 7 )
Induce interaction with:
Btk (mouse) ( 6 )

References 

1

Ko JS, et al. (2021) Ssu72 phosphatase directly binds to ZAP-70, thereby providing fine-tuning of TCR signaling and preventing spontaneous inflammation. Proc Natl Acad Sci U S A 118
34452999   Curated Info

2

Block H, et al. (2012) Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury. J Exp Med 209, 407-21
22291096   Curated Info

3

Bezman NA, et al. (2008) Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo. J Exp Med 205, 1775-88
18663126   Curated Info

4

Jordan MS, et al. (2008) Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76. Immunity 28, 359-69
18342008   Curated Info

5

Jordan MS, et al. (2006) Functional hierarchy of the N-terminal tyrosines of SLP-76. J Immunol 176, 2430-8
16456002   Curated Info

6

Kettner A, et al. (2003) Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (Fc epsilon RI) in mast cells. Mol Cell Biol 23, 2395-406
12640123   Curated Info

7

Herndon TM, Shan XC, Tsokos GC, Wange RL (2001) ZAP-70 and SLP-76 regulate protein kinase C-theta and NF-kappa B activation in response to engagement of CD3 and CD28. J Immunol 166, 5654-64
11313406   Curated Info