Tyr112
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Home > Phosphorylation Site Page: > Tyr112  -  SLP76 (mouse)

Site Information
WSSFEDDyESPNDDD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448218

In vivo Characterization
Methods used to characterize site in vivo:
flow cytometry ( 4 ) , mutation of modification site ( 1 , 2 , 3 , 4 , 5 , 6 ) , phospho-antibody ( 2 , 3 , 4 , 5 , 7 ) , western blotting ( 2 , 3 , 4 , 5 )
Relevant cell line - cell type - tissue:
Jurkat (T lymphocyte) ( 2 , 4 , 6 ) , mast-bone marrow ( 5 ) , platelet-blood [SLP76 (mouse), homozygous knockout] ( 2 ) , renal ( 1 ) , SF9 ( 7 ) , thymocyte ( 3 )

Upstream Regulation
Treatments:
antibody ( 4 , 5 ) , convulxin ( 2 ) , vanadate ( 4 )

Downstream Regulation
Effects of modification on SLP76:
molecular association, regulation ( 5 , 7 ) , phosphorylation ( 2 , 3 , 5 )
Effects of modification on biological processes:
apoptosis, altered ( 3 ) , cell adhesion, altered ( 2 ) , cell differentiation, altered ( 3 ) , cytoskeletal reorganization ( 2 ) , signaling pathway regulation ( 1 ) , transcription, altered ( 4 ) , transcription, induced ( 6 )
Induce interaction with:
VAV1 (mouse) ( 5 , 7 )

References 

1

Block H, et al. (2012) Crucial role of SLP-76 and ADAP for neutrophil recruitment in mouse kidney ischemia-reperfusion injury. J Exp Med 209, 407-21
22291096   Curated Info

2

Bezman NA, et al. (2008) Requirements of SLP76 tyrosines in ITAM and integrin receptor signaling and in platelet function in vivo. J Exp Med 205, 1775-88
18663126   Curated Info

3

Jordan MS, et al. (2008) Complementation in trans of altered thymocyte development in mice expressing mutant forms of the adaptor molecule SLP76. Immunity 28, 359-69
18342008   Curated Info

4

Jordan MS, et al. (2006) Functional hierarchy of the N-terminal tyrosines of SLP-76. J Immunol 176, 2430-8
16456002   Curated Info

5

Kettner A, et al. (2003) Structural requirements of SLP-76 in signaling via the high-affinity immunoglobulin E receptor (Fc epsilon RI) in mast cells. Mol Cell Biol 23, 2395-406
12640123   Curated Info

6

Herndon TM, Shan XC, Tsokos GC, Wange RL (2001) ZAP-70 and SLP-76 regulate protein kinase C-theta and NF-kappa B activation in response to engagement of CD3 and CD28. J Immunol 166, 5654-64
11313406   Curated Info

7

Raab M, da Silva AJ, Findell PR, Rudd CE (1997) Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta/CD3 induction of interleukin-2. Immunity 6, 155-64
9047237   Curated Info