|
Powered by Cell Signaling Technology |
Site Information |
---|
GGAkrHRkVLrDNIQ SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 465128 |
In vivo Characterization | |
---|---|
Methods used to characterize site in vivo: | |
Disease tissue studied: | |
Relevant cell line - cell type - tissue: |
Upstream Regulation | |
---|---|
Regulatory protein: | |
Treatments: |
Downstream Regulation | |
---|---|
Effects of modification on H4: | |
Effects of modification on biological processes: | |
Induce interaction with: | |
Inhibit interaction with: |
References | |
---|---|
Lou J, et al. (2020) Spatiotemporal dynamics of 53BP1 dimer recruitment to a DNA double strand break. Nat Commun 11, 5776
33188174 Curated Info |
|
Zhang F, et al. (2020) Nudix Hydrolase NUDT16 Regulates 53BP1 Protein by Reversing 53BP1 ADP-Ribosylation. Cancer Res 80, 999-1010
31911551 Curated Info |
|
Wang L, et al. (2020) miR24-2 Promotes Malignant Progression of Human Liver Cancer Stem Cells by Enhancing Tyrosine Kinase Src Epigenetically. Mol Ther 28, 572-586
31732298 Curated Info |
|
Abshiru NA, et al. (2020) Targeted detection and quantitation of histone modifications from 1,000 cells. PLoS One 15, e0240829
33104722 Curated Info |
|
Paquin KL, et al. (2019) FANCD2 Binding to H4K20me2 via a Methyl-Binding Domain Is Essential for Efficient DNA Cross-Link Repair. Mol Cell Biol 39
31085681 Curated Info |
|
Clouaire T, et al. (2018) Comprehensive Mapping of Histone Modifications at DNA Double-Strand Breaks Deciphers Repair Pathway Chromatin Signatures. Mol Cell
30270107 Curated Info |
|
Wang T, Holt MV, Young NL (2018) The histone H4 proteoform dynamics in response to SUV4-20 inhibition reveals single molecule mechanisms of inhibitor resistance. Epigenetics Chromatin
29880017 Curated Info |
|
Canny MD, et al. (2018) Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR-Cas9 genome-editing efficiency. Nat Biotechnol 36, 95-102
29176614 Curated Info |
|
Hu Q, et al. (2017) Mechanisms of Ubiquitin-Nucleosome Recognition and Regulation of 53BP1 Chromatin Recruitment by RNF168/169 and RAD18. Mol Cell
28506460 Curated Info |
|
Gursoy-Yuzugullu O, et al. (2017) Epigenetic therapy with inhibitors of histone methylation suppresses DNA damage signaling and increases glioma cell radiosensitivity. Oncotarget 8, 24518-24532
28445939 Curated Info |
|
Dran¿¿ P, et al. (2017) TIRR regulates 53BP1 by masking its histone methyl-lysine binding function. Nature
28241136 Curated Info |
|
Jacquet K, et al. (2016) The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation. Mol Cell 62, 409-21
27153538 Curated Info |
|
Nguyen H, et al. (2015) LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2. J Biol Chem 290, 13641-53
25825497 Curated Info |
|
Chou RH, et al. (2014) EGFR Modulates DNA Synthesis and Repair through Tyr Phosphorylation of Histone H4. Dev Cell 30, 224-37
25073158 Curated Info |
|
Hsiao KY, Mizzen CA (2013) Histone H4 deacetylation facilitates 53BP1 DNA damage signaling and double-strand break repair. J Mol Cell Biol 5, 157-65
23329852 Curated Info |
|
Cao XJ, Arnaudo AM, Garcia BA (2013) Large-scale global identification of protein lysine methylation in vivo. Epigenetics 8, 477-85
23644510 Curated Info |
|
Jack AP, et al. (2013) H3K56me3 Is a Novel, Conserved Heterochromatic Mark That Largely but Not Completely Overlaps with H3K9me3 in Both Regulation and Localization. PLoS One 8, e51765
23451023 Curated Info |
|
Lai Z, et al. (2013) Msl2 is a novel component of the vertebrate DNA damage response. PLoS One 8, e68549
23874665 Curated Info |
|
Uhlmann T, et al. (2012) A method for large-scale identification of protein arginine methylation. Mol Cell Proteomics 11, 1489-99
22865923 Curated Info |
|
Cuomo A, Moretti S, Minucci S, Bonaldi T (2011) SILAC-based proteomic analysis to dissect the "histone modification signature" of human breast cancer cells. Amino Acids 41, 387-99
20617350 Curated Info |
|
Pei H, et al. (2011) MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites. Nature 470, 124-8
21293379 Curated Info |
|
Fortschegger K, et al. (2010) PHF8 targets histone methylation and RNA polymerase II to activate transcription. Mol Cell Biol 30, 3286-98
20421419 Curated Info |
|
Giunta S, Belotserkovskaya R, Jackson SP (2010) DNA damage signaling in response to double-strand breaks during mitosis. J Cell Biol 190, 197-207
20660628 Curated Info |
|
Darwanto A, et al. (2010) A modified "cross-talk" between histone H2B Lys-120 ubiquitination and H3 Lys-79 methylation. J Biol Chem 285, 21868-76
20442396 Curated Info |
|
Kleine-Kohlbrecher D, et al. (2010) A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation. Mol Cell 38, 165-78
20346720 Curated Info |
|
Zee BM, et al. (2010) In vivo residue-specific histone methylation dynamics. J Biol Chem 285, 3341-50
19940157 Curated Info |
|
Possemato A (2009) CST Curation Set: 8356; Year: 2009; Biosample/Treatment: cell line, Jurkat/calyculin_A & pervanadate; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: m2K
Curated Info |
|
Yan Q, et al. (2009) BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response. Mol Cell 36, 110-20
19818714 Curated Info |
|
Spektor TM, Rice JC (2009) Identification and characterization of posttranslational modification-specific binding proteins in vivo by mammalian tethered catalysis. Proc Natl Acad Sci U S A 106, 14808-13
19706462 Curated Info |
|
Couture JF, et al. (2008) Structural origins for the product specificity of SET domain protein methyltransferases. Proc Natl Acad Sci U S A 105, 20659-64
19088188 Curated Info |
|
Gurard-Levin ZA, Mrksich M (2008) The activity of HDAC8 depends on local and distal sequences of its peptide substrates. Biochemistry 47, 6242-50
18470998 Curated Info |
|
Pesavento JJ, et al. (2008) Combinatorial modification of human histone H4 quantitated by two-dimensional liquid chromatography coupled with top down mass spectrometry. J Biol Chem 283, 14927-37
18381279 Curated Info |
|
Pesavento JJ, Yang H, Kelleher NL, Mizzen CA (2008) Certain and progressive methylation of histone H4 at lysine 20 during the cell cycle. Mol Cell Biol 28, 468-86
17967882 Curated Info |
|
Bonenfant D, et al. (2007) Analysis of dynamic changes in post-translational modifications of human histones during cell cycle by mass spectrometry. Mol Cell Proteomics 6, 1917-32
17644761 Curated Info |
|
Botuyan MV, et al. (2006) Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell 127, 1361-73
17190600 Curated Info |
|
Beck HC, et al. (2006) Quantitative proteomic analysis of post-translational modifications of human histones. Mol Cell Proteomics 5, 1314-25
16627869 Curated Info |
|
Metzger E, et al. (2005) LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription. Nature 437, 436-9
16079795 Curated Info |
|
Shi Y, et al. (2004) Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 119, 941-53
15620353 Curated Info |
|
Ong SE, Mittler G, Mann M (2004) Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. Nat Methods 1, 119-26
15782174 Curated Info |
|
Zhang K, et al. (2002) Histone acetylation and deacetylation: identification of acetylation and methylation sites of HeLa histone H4 by mass spectrometry. Mol Cell Proteomics 1, 500-8
12239278 Curated Info |