Tyr127
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Home > Phosphorylation Site Page: > Tyr127  -  AFAP1L1 (mouse)

Site Information
KPPPEDYyEEALPLG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 41691500

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 )
Disease tissue studied:
bone cancer ( 1 ) , osteosarcoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
LYN (human) ( 1 )

Downstream Regulation
Effects of modification on AFAP1L1:
molecular association, regulation ( 1 )
Effects of modification on biological processes:
cell motility, induced ( 1 ) , cytoskeletal reorganization ( 1 )
Induce interaction with:
VAV2 (human) ( 1 )

References 

1

Tie SR, et al. (2016) Regulation of sarcoma cell migration, invasion and invadopodia formation by AFAP1L1 through a phosphotyrosine-dependent pathway. Oncogene 35, 2098-111
26212012   Curated Info