Thr476
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Home > Phosphorylation Site Page: > Thr476  -  IL2RB (human)

Site Information
PQPLGPPtPGVPDLV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 41591300

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , YT ( 1 )

Upstream Regulation
Putative in vivo kinases:
ERK1 (human) ( 1 ) , ERK2 (human) ( 1 )
Phosphatases, in vitro:
PPP1CA (human) ( 1 )
Treatments:
calyculin_A ( 1 ) , FR180204 ( 1 ) , IL-15 ( 1 ) , IL-2 ( 1 ) , KT5720 ( 1 ) , tofacitinib ( 1 ) , Trametinib ( 1 ) , wortmannin ( 1 )

Downstream Regulation
Effects of modification on biological processes:
transcription, induced ( 1 )

References 

1

Ruiz-Medina BE, Ross JA, Kirken RA (2015) Interleukin-2 Receptor β Thr-450 Phosphorylation Is a Positive Regulator for Receptor Complex Stability and Activation of Signaling Molecules. J Biol Chem 290, 20972-83
26152718   Curated Info

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