Tyr1069
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Home > Phosphorylation Site Page: > Tyr1069  -  EGFR (mouse)

Site Information
EDAFLQRyssDPtGA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448056

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 4 ) , mutation of modification site ( 5 , 8 ) , phospho-antibody ( 1 , 2 , 3 , 5 , 6 , 7 ) , western blotting ( 1 , 2 , 3 , 5 )
Disease tissue studied:
bladder cancer ( 3 )
Relevant cell line - cell type - tissue:
bladder ( 3 ) , CHO (fibroblast) [EphB1 (human), transfection] ( 8 ) , GT1-7 (neuron) ( 7 ) , keratinocyte-skin ( 6 ) , MEF (fibroblast) [PTP1B (mouse), homozygous knockout] ( 4 ) , MEF (fibroblast) ( 4 ) , prostate ( 2 )

Upstream Regulation
Regulatory protein:
EGFR (mouse) ( 1 ) , ERG (mouse) ( 2 ) , P38A (mouse) ( 5 ) , PTP1B (mouse) ( 4 )
Kinases, in vitro:
EGFR (mouse) ( 8 )
Phosphatases, in vitro:
PTP1B (mouse) ( 4 )
Treatments:
AG1478 ( 1 ) , anisomycin ( 5 ) , astragaloside_IV ( 1 ) , cetuximab ( 3 ) , EGF ( 4 , 5 ) , GnRH ( 7 ) , light ( 3 ) , SB202190 ( 5 ) , UV ( 6 )

Downstream Regulation
Effects of modification on EGFR:
molecular association, regulation ( 8 ) , phosphorylation ( 5 ) , protein degradation ( 5 , 8 )
Effects of modification on biological processes:
apoptosis, inhibited ( 6 ) , cell motility, altered ( 5 )
Induce interaction with:
CBL (human) ( 8 )

References 

1

Gu DM, et al. (2015) EGFR mediates astragaloside IV-induced Nrf2 activation to protect cortical neurons against in vitro ischemia/reperfusion damages. Biochem Biophys Res Commun 457, 391-7
25582778   Curated Info

2

Drake JM, et al. (2012) Oncogene-specific activation of tyrosine kinase networks during prostate cancer progression. Proc Natl Acad Sci U S A 109, 1643-8
22307624   Curated Info

3

Bhuvaneswari R, Gan YY, Soo KC, Olivo M (2009) Targeting EGFR with photodynamic therapy in combination with Erbitux enhances in vivo bladder tumor response. Mol Cancer 8, 94
19878607   Curated Info

4

Mertins P, et al. (2008) Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics. Mol Cell Proteomics 7, 1763-77
18515860   Curated Info

5

Frey MR, Dise RS, Edelblum KL, Polk DB (2006) p38 kinase regulates epidermal growth factor receptor downregulation and cellular migration. EMBO J 25, 5683-92
17139251   Curated Info

6

El-Abaseri TB, Putta S, Hansen LA (2006) Ultraviolet irradiation induces keratinocyte proliferation and epidermal hyperplasia through the activation of the epidermal growth factor receptor. Carcinogenesis 27, 225-31
16123117   Curated Info

7

Shah BH, Soh JW, Catt KJ (2003) Dependence of gonadotropin-releasing hormone-induced neuronal MAPK signaling on epidermal growth factor receptor transactivation. J Biol Chem 278, 2866-75
12446705   Curated Info

8

Levkowitz G, et al. (1999) Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. Mol Cell 4, 1029-40
10635327   Curated Info

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