Tyr1018
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Site Information
DVVDADEyLIPQQGF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448055

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 ) , phospho-antibody ( 1 , 3 , 4 ) , western blotting ( 1 , 3 )
Disease tissue studied:
bladder cancer ( 1 )
Relevant cell line - cell type - tissue:
bladder ( 1 ) , keratinocyte-skin ( 4 ) , MEF (fibroblast) [PTP1B (mouse), homozygous knockout] ( 2 ) , MEF (fibroblast) ( 2 )

Upstream Regulation
Treatments:
cetuximab ( 1 ) , EGF ( 2 , 3 ) , light ( 1 ) , SB202190 ( 3 ) , UV ( 4 )

Downstream Regulation
Effects of modification on biological processes:
apoptosis, inhibited ( 4 )

References 

1

Bhuvaneswari R, Gan YY, Soo KC, Olivo M (2009) Targeting EGFR with photodynamic therapy in combination with Erbitux enhances in vivo bladder tumor response. Mol Cancer 8, 94
19878607   Curated Info

2

Mertins P, et al. (2008) Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics. Mol Cell Proteomics 7, 1763-77
18515860   Curated Info

3

Frey MR, Dise RS, Edelblum KL, Polk DB (2006) p38 kinase regulates epidermal growth factor receptor downregulation and cellular migration. EMBO J 25, 5683-92
17139251   Curated Info

4

El-Abaseri TB, Putta S, Hansen LA (2006) Ultraviolet irradiation induces keratinocyte proliferation and epidermal hyperplasia through the activation of the epidermal growth factor receptor. Carcinogenesis 27, 225-31
16123117   Curated Info

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