Lys137
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Home > Acetylation Site Page: > Lys137  -  DDX21 (human)

Site Information
PkKMKKEkEMNGETR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 41518316

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 ) , modification-specific antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 1 ) , Jurkat (T lymphocyte) ( 2 ) , MCF-7 (breast cell) ( 1 )

Upstream Regulation
Treatments:
nicotinamide ( 1 )

Downstream Regulation
Effects of modification on DDX21:
enzymatic activity, inhibited ( 1 )
Effects of modification on biological processes:
transcription, inhibited ( 1 )

References 

1

Song C, Hotz-Wagenblatt A, Voit R, Grummt I (2017) SIRT7 and the DEAD-box helicase DDX21 cooperate to resolve genomic R loops and safeguard genome stability. Genes Dev
28790157   Curated Info

2

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info

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