Ser584
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Home > Phosphorylation Site Page: > Ser584  -  HDAC4 (human)

Site Information
EPGQRQPsEQELLFR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 41452201

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 , 4 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
HER2 positive breast cancer ( 2 ) , luminal A breast cancer ( 2 ) , luminal B breast cancer ( 2 ) , breast cancer, triple negative ( 2 ) , leukemia ( 1 ) , chronic myelogenous leukemia ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
PKACA (human) ( 1 )
Kinases, in vitro:
PKACA (human) ( 1 )
Treatments:
cAMP_analog ( 1 ) , H-89 ( 1 ) , NKH_477 ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on HDAC4:
activity, induced ( 1 )
Effects of modification on biological processes:
transcription, inhibited ( 1 )

References 

1

Doddi SK, Kummari G, M V J, Kalle AM (2019) Protein kinase A-mediated novel Serine 584 phosphorylation of HDAC4. Biochem Cell Biol
30661366   Curated Info

2

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

3

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

4

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info