Ser682
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Home > Phosphorylation Site Page: > Ser682  -  SIRT1 (human)

Site Information
SDSGTCQsPSLEEPM   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 41401500

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , microscopy-colocalization with upstream kinase ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
bone cancer ( 1 ) , lung cancer ( 1 ) , non-small cell lung cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
HIPK2 (human) ( 1 )
Kinases, in vitro:
HIPK2 (human) ( 1 )
Treatments:
adriamycin ( 1 )

Downstream Regulation
Effects of modification on SIRT1:
intracellular localization ( 1 )
Effects of modification on biological processes:
apoptosis, induced ( 1 ) , transcription, induced ( 1 )

References 

1

Conrad E, et al. (2016) HIPK2 restricts SIRT1 activity upon severe DNA damage by a phosphorylation-controlled mechanism. Cell Death Differ 23, 110-22
26113041   Curated Info