Ser203
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Home > Phosphorylation Site Page: > Ser203  -  STF-1 (mouse)

Site Information
EYPEPYAsPPQQPGP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447603

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 6 ) , immunoprecipitation ( 2 , 3 ) , mutation of modification site ( 2 , 3 , 4 , 5 , 6 ) , peptide sequencing ( 6 ) , phospho-antibody ( 4 , 5 ) , phosphoamino acid analysis ( 6 ) , phosphopeptide mapping ( 6 ) , western blotting ( 4 , 5 )
Disease tissue studied:
adrenal cancer ( 2 ) , adrenocortical carcinoma ( 2 ) , breast cancer ( 6 ) , gestational cancer ( 6 ) , gestational trophoblastic choriocarcinoma ( 6 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 3 ) , 3T3 (fibroblast) [RAF1 (mouse)] ( 5 ) , alphaT3-1 (pituitary cell) ( 4 ) , COS (fibroblast) ( 2 , 6 ) , JEG-3 (uterine) ( 6 ) , MCF-7 (breast cell) ( 6 ) , Y-1 (adrenal cortical) ( 2 , 5 )

Upstream Regulation
Regulatory protein:
DUSP1 (human) ( 4 ) , DUSP1 (mouse) ( 5 ) , RAF1 (human) ( 6 ) , STF-1 (mouse) ( 2 )
Putative in vivo kinases:
CDK7 (human) ( 2 ) , ERK1 (mouse) ( 4 , 5 ) , ERK2 (human) ( 5 , 6 )
Kinases, in vitro:
ERK2 (human) ( 6 )
Treatments:
EGF ( 6 ) , GF109203X ( 4 ) , PACAP ( 4 ) , seliciclib ( 2 ) , U0126 ( 2 , 4 )

Downstream Regulation
Effects of modification on STF-1:
activity, induced ( 1 , 2 , 5 , 6 ) , molecular association, regulation ( 6 ) , protein conformation ( 4 , 5 )
Effects of modification on biological processes:
transcription, altered ( 2 , 5 ) , transcription, induced ( 1 , 4 )
Induce interaction with:
GRIP1 (human) ( 6 ) , SMRT (human) ( 6 )

References 

1

Wang CM, Liu R, Wang L, Yang WH (2013) Acidic residue Glu199 increases SUMOylation level of nuclear hormone receptor NR5A1. Int J Mol Sci 14, 22331-45
24232453   Curated Info

2

Yang WH, et al. (2009) SUMOylation inhibits SF-1 activity by reducing CDK7-mediated serine 203 phosphorylation. Mol Cell Biol 29, 613-25
19015234   Curated Info

3

Campbell LA, et al. (2008) Decreased recognition of SUMO-sensitive target genes following modification of SF-1 (NR5A1). Mol Cell Biol 28, 7476-86
18838537   Curated Info

4

Fowkes RC, et al. (2003) Steroidogenic factor-1 and the gonadotrope-specific element enhance basal and pituitary adenylate cyclase-activating polypeptide-stimulated transcription of the human glycoprotein hormone alpha-subunit gene in gonadotropes. Mol Endocrinol 17, 2177-88
12920232   Curated Info

5

Desclozeaux M, et al. (2002) Phosphorylation and intramolecular stabilization of the ligand binding domain in the nuclear receptor steroidogenic factor 1. Mol Cell Biol 22, 7193-203
12242296   Curated Info

6

Hammer GD, et al. (1999) Phosphorylation of the nuclear receptor SF-1 modulates cofactor recruitment: integration of hormone signaling in reproduction and stress. Mol Cell 3, 521-6
10230405   Curated Info

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