Thr372

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Home > Phosphorylation Site Page: > Thr372 - ATM (human)

Site Information
EIsQSyTttQRESSD SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 411189200

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:	bone cancer ( 1 )
Relevant cell line - cell type - tissue:	HEK293T (epithelial) ( 1 ) , U2OS (bone cell) ( 1 )

Downstream Regulation
Effects of modification on ATM:	enzymatic activity, inhibited ( 1 ) , protein conformation ( 1 )
Effects of modification on biological processes:	apoptosis, inhibited ( 1 ) , cell cycle regulation ( 1 )

References
1	Zhou Y, et al. (2017) Regulation of the DNA Damage Response by DNA-PKcs Inhibitory Phosphorylation of ATM. Mol Cell 65, 91-104 27939942 Curated Info

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