Thr361
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Home > Phosphorylation Site Page: > Thr361  -  DOR-1 (human)

Site Information
RERVtACtPsDGPGG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448551

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 3 ) , phospho-antibody ( 1 , 3 ) , western blotting ( 1 , 3 )
Disease tissue studied:
breast cancer ( 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
GRK5 (human) ( 1 ) , GRK6 (human) ( 1 )
Putative in vivo kinases:
GRK2 (human) ( 1 ) , GRK3 (human) ( 1 )
Putative upstream phosphatases:
PPP1CA (human) ( 1 ) , PPP1CB (human) ( 1 )
Treatments:
AG1478 ( 3 ) , calyculin_A ( 1 ) , Cmpd101 ( 1 ) , DADLE ( 1 ) , deltorphin_I ( 1 ) , deltorphin_II ( 1 ) , DPDPE ( 1 , 3 ) , EGF ( 3 ) , morphine ( 1 ) , naloxone ( 1 ) , naltrexone ( 1 ) , naltrindole ( 1 ) , NKH_477 ( 1 ) , okadaic_acid ( 1 ) , phorbol_ester ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on DOR-1:
receptor inactivation, induced ( 1 ) , receptor internalization, induced ( 1 )

References 

1

Mann A, et al. (2020) Agonist-induced phosphorylation bar code and differential post-activation signaling of the delta opioid receptor revealed by phosphosite-specific antibodies. Sci Rep 10, 8585
32444688   Curated Info

2

Shiromizu T, et al. (2013) Identification of missing proteins in the neXtProt database and unregistered phosphopeptides in the PhosphoSitePlus database as part of the Chromosome-centric Human Proteome Project. J Proteome Res 12, 2414-21
23312004   Curated Info

3

Chen Y, et al. (2008) EGF Transregulates Opioid Receptors through EGFR-mediated GRK2 Phosphorylation and Activation. Mol Biol Cell 19, 2973-83
18463167   Curated Info