Tyr523
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Home > Phosphorylation Site Page: > Tyr523  -  PSD-95 (human)

Site Information
REDSVLSyETVTQME   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 4093600

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 , 3 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 )
Disease tissue studied:
neuroblastoma ( 2 )
Relevant cell line - cell type - tissue:
'neuron, cortical'-brain ( 1 ) , COS (fibroblast) ( 3 ) , HEK293T (epithelial) ( 1 ) , SH-SY5Y (neural crest) ( 2 )

Upstream Regulation
Regulatory protein:
Src (human) ( 2 )
Putative in vivo kinases:
Fyn (human) ( 2 , 3 ) , Src (human) ( 1 , 3 )
Kinases, in vitro:
Fyn (human) ( 3 ) , Src (human) ( 3 )
Treatments:
beta-amyloid ( 2 ) , bicuculline ( 1 ) , deoxygenation ( 2 ) , MK801 ( 1 ) , NMDA ( 1 ) , PP2 ( 1 ) , siRNA ( 2 )

Downstream Regulation
Effects of modification on PSD-95:
activity, induced ( 1 ) , molecular association, regulation ( 1 ) , phosphorylation ( 1 )
Effects of modification on biological processes:
apoptosis, induced ( 2 ) , neural plasticity ( 1 )
Induce interaction with:
Pyk2 (human) ( 1 )

References 

1

Zhao C, et al. (2015) The Upregulation of NR2A-Containing N-Methyl-D-Aspartate Receptor Function by Tyrosine Phosphorylation of Postsynaptic Density 95 Via Facilitating Src/Proline-Rich Tyrosine Kinase 2 Activation. Mol Neurobiol 51, 500-11
24981431   Curated Info

2

Du CP, Tan R, Hou XY (2012) Fyn Kinases Play a Critical Role in Neuronal Apoptosis Induced by Oxygen and Glucose Deprivation or Amyloid-β Peptide Treatment. CNS Neurosci Ther 18, 754-61
22709448   Curated Info

3

Du CP, et al. (2009) Increased tyrosine phosphorylation of PSD-95 by Src family kinases after brain ischaemia. Biochem J 417, 277-85
18721130   Curated Info