Lys436
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Home > Sumoylation Site Page: > Lys436  -  TOP1 (human)

Site Information
LNPSSRIkGEKDWQk   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 40724401

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:

Downstream Regulation
Effects of modification on TOP1:
enzymatic activity, inhibited ( 1 ) , molecular association, regulation ( 1 )
Induce interaction with:
POLR2A (human) ( 1 )

References 

1

Li M, et al. (2015) RECQ5-dependent SUMOylation of DNA topoisomerase I prevents transcription-associated genome instability. Nat Commun 6, 6720
25851487   Curated Info