Thr236
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Home > Phosphorylation Site Page: > Thr236  -  SOX9 (human)

Site Information
GQSQGPPtPPtTPKT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 40722389

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 2 , 3 , 4 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 , 2 )
Disease tissue studied:
brain cancer ( 1 ) , medulloblastoma ( 1 ) , breast cancer ( 4 ) , HER2 positive breast cancer ( 3 ) , luminal A breast cancer ( 3 ) , luminal B breast cancer ( 3 ) , breast cancer, triple negative ( 3 ) , colorectal cancer ( 2 ) , colorectal carcinoma ( 2 ) , lung cancer ( 2 ) , non-small cell lung cancer ( 2 ) , non-small cell lung adenocarcinoma ( 2 ) , non-small cell large cell lung carcinoma ( 2 )
Relevant cell line - cell type - tissue:
A549 (pulmonary) ( 2 ) , breast ( 3 ) , Daoy ( 1 ) , HCT116 (intestinal) ( 2 ) , HMLER ('stem, breast cancer') [CXCR4 (human), knockdown] ( 4 ) , HMLER ('stem, breast cancer') ( 4 ) , NCI-H1299 (pulmonary) ( 2 ) , NCI-H460 (pulmonary) ( 2 )

Upstream Regulation
Kinases, in vitro:
GSK3B (human) ( 1 , 2 )

Downstream Regulation
Effects of modification on SOX9:
molecular association, regulation ( 1 ) , protein degradation ( 1 , 2 ) , ubiquitination ( 1 , 2 )
Effects of modification on biological processes:
apoptosis, induced ( 2 ) , transcription, altered ( 1 )
Induce interaction with:
FBXW7 (human) ( 1 , 2 )

References 

1

Suryo Rahmanto A, et al. (2016) FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma. EMBO J 35, 2192-2212
27625374   Curated Info

2

Hong X, et al. (2016) SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage. Nucleic Acids Res 44, 8855-8869
27566146   Curated Info

3

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

4

Yi T, et al. (2014) Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells. Proc Natl Acad Sci U S A 111, E2182-90
24782546   Curated Info

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