Ser506
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Home > Phosphorylation Site Page: > Ser506  -  Tau (mouse)

Site Information
GsRsRtPsLPtPPtR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447929

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 2 ) , mass spectrometry ( 1 , 4 , 5 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 15 ) , microscopy-colocalization with upstream kinase ( 19 ) , phospho-antibody ( 2 , 14 , 17 , 18 , 19 ) , western blotting ( 2 , 14 , 17 , 19 )
Disease tissue studied:
Alzheimer's disease ( 2 , 19 )
Relevant cell line - cell type - tissue:
'brain, cerebellum' ( 17 ) , 'brain, cerebral cortex' ( 12 ) , 'brain, cerebrum' ( 17 ) , 'brain, embryonic' ( 13 , 19 ) , 'brain, hippocampus' ( 19 ) , 'neuron, hippocampal, CA1 pyramidal'-brain ( 2 ) , brain ( 4 , 5 , 7 , 8 , 10 , 11 , 14 , 18 , 19 ) , heart ( 15 ) , liver ( 1 , 9 )

Upstream Regulation
Regulatory protein:
NPC1 (mouse) ( 17 )
Kinases, in vitro:
PKACA (human) ( 19 )
Treatments:
fasting ( 16 ) , glucose_starvation ( 18 ) , hibernating ( 14 ) , olfactory bulbectomy ( 2 ) , summer-active ( 14 )

Downstream Regulation
Effects of modification on Tau:
molecular association, regulation ( 19 )
Induce interaction with:
AKAP5 (human) ( 19 ) , PKACB (human) ( 19 ) , PKAR2B (human) ( 19 )

Disease / Diagnostics Relevance
Relevant diseases:
Alzheimer's disease ( 2 , 19 )

References 

1

Robles MS, Humphrey SJ, Mann M (2017) Phosphorylation Is a Central Mechanism for Circadian Control of Metabolism and Physiology. Cell Metab 25, 118-127
27818261   Curated Info

2

Li K, et al. (2016) Olfactory Deprivation Hastens Alzheimer-Like Pathologies in a Human Tau-Overexpressed Mouse Model via Activation of cdk5. Mol Neurobiol 53, 391-401
25465240   Curated Info

3

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

4

Trinidad JC, et al. (2012) Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics 11, 215-29
22645316   Curated Info

5

Goswami T, et al. (2012) Comparative phosphoproteomic analysis of neonatal and adult murine brain. Proteomics 12, 2185-9
22807455   Curated Info

6

Thornton C, et al. (2011) AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure. Biochem J 434, 503-12
21204788   Curated Info

7

Possemato A (2010) CST Curation Set: 9879; Year: 2010; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]XP Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser) 14-3-3 Binding Motif (4E2) Mouse mAb Cat#: 9606
Curated Info

8

Possemato A (2010) CST Curation Set: 9878; Year: 2010; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]XP Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser) 14-3-3 Binding Motif (4E2) Mouse mAb Cat#: 9606
Curated Info

9

Possemato A (2010) CST Curation Set: 9882; Year: 2010; Biosample/Treatment: tissue, liver/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]XP Antibodies Used to Purify Peptides prior to LCMS: Phospho-(Ser) 14-3-3 Binding Motif Antibody Cat#: 9601
Curated Info

10

Wiśniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9
20415495   Curated Info

11

Zhou J (2010) CST Curation Set: 9271; Year: 2010; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: (F/Y)XpS
Curated Info

12

Tweedie-Cullen RY, Reck JM, Mansuy IM (2009) Comprehensive mapping of post-translational modifications on synaptic, nuclear, and histone proteins in the adult mouse brain. J Proteome Res 8, 4966-82
19737024   Curated Info

13

Zhou J (2009) CST Curation Set: 7373; Year: 2009; Biosample/Treatment: tissue, brain/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: YXp[ST]
Curated Info

14

Su B, et al. (2008) Physiological regulation of tau phosphorylation during hibernation. J Neurochem 105, 2098-108
18284615   Curated Info

15

Guo A (2007) CST Curation Set: 3020; Year: 2007; Biosample/Treatment: tissue, heart/-; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXT-P) (81E12B5) Rabbit mAb Cat#: 10003
Curated Info

16

Li X, Lu F, Wang JZ, Gong CX (2006) Concurrent alterations of O-GlcNAcylation and phosphorylation of tau in mouse brains during fasting. Eur J Neurosci 23, 2078-86
16630055   Curated Info

17

Yu W, Ko M, Yanagisawa K, Michikawa M (2005) Neurodegeneration in heterozygous Niemann-Pick type C1 (NPC1) mouse: implication of heterozygous NPC1 mutations being a risk for tauopathy. J Biol Chem 280, 27296-302
15919659   Curated Info

18

Liu F, et al. (2004) O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease. Proc Natl Acad Sci U S A 101, 10804-9
15249677   Curated Info

19

Jicha GA, et al. (1999) cAMP-dependent protein kinase phosphorylations on tau in Alzheimer's disease. J Neurosci 19, 7486-94
10460255   Curated Info