Thr107
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Home > Phosphorylation Site Page: > Thr107  -  ATF-4 (human)

Site Information
LGIDDLEtMPDDLLt   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 40420006

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
thyroid cancer ( 1 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 1 ) , TT (thyroid cell) ( 1 )

Upstream Regulation
Putative in vivo kinases:
Ret (human) ( 1 )
Kinases, in vitro:
Ret (human) ( 1 )

Downstream Regulation
Effects of modification on ATF-4:
protein degradation ( 1 )
Effects of modification on biological processes:
transcription, inhibited ( 1 )

References 

1

Bagheri-Yarmand R, et al. (2015) A novel dual kinase function of the RET proto-oncogene negatively regulates activating transcription factor 4-mediated apoptosis. J Biol Chem 290, 11749-61
25795775   Curated Info

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