Ser518
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Home > Phosphorylation Site Page: > Ser518  -  CRMP-2 (rat)

Site Information
KTVtPASsAKTsPAK   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448081

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 5 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 5 )
Relevant cell line - cell type - tissue:
brain ( 5 ) , neuron-'brain, hippocampus' ( 1 ) , REF (fibroblast) ( 2 )

Upstream Regulation
Putative in vivo kinases:
GSK3A (human) ( 2 ) , GSK3B (rat) ( 1 )
Kinases, in vitro:
GSK3B (human) ( 3 , 4 )
Treatments:
AR-A014418 ( 2 ) , CHIR99021 ( 1 ) , EGTA ( 5 ) , glycerol_phosphate ( 5 ) , KFl ( 5 ) , microcystin-LR ( 5 ) , okadaic_acid ( 5 ) , sodium_phosphate ( 5 ) , sodium_pyrophosphate ( 5 ) , vanadate ( 5 )

Downstream Regulation
Effects of modification on CRMP-2:
molecular association, regulation ( 1 , 2 ) , protein degradation ( 1 ) , receptor recycling, inhibited ( 1 )
Effects of modification on biological processes:
neural plasticity ( 1 )
Inhibit interaction with:
ROCK2 (rat) ( 2 ) , TUBA1A (human) ( 1 ) , endophilin A2 (human) ( 1 )

References 

1

Zhang J, et al. (2020) Collapsin Response Mediator Protein 2 and Endophilin2 Coordinate Regulation of AMPA Receptor GluA1 Subunit Recycling. Front Mol Neurosci 13, 128
32848595   Curated Info

2

Morgan-Fisher M, Couchman JR, Yoneda A (2013) Phosphorylation and mRNA Splicing of Collapsin Response Mediator Protein-2 Determine Inhibition of Rho-associated Protein Kinase (ROCK) II Function in Carcinoma Cell Migration and Invasion. J Biol Chem 288, 31229-40
24036111   Curated Info

3

Cole AR, et al. (2004) GSK-3 phosphorylation of the Alzheimer epitope within collapsin response mediator proteins regulates axon elongation in primary neurons. J Biol Chem 279, 50176-80
15466863   Curated Info

4

Brown M, et al. (2004) Alpha2-chimaerin, cyclin-dependent Kinase 5/p35, and its target collapsin response mediator protein-2 are essential components in semaphorin 3A-induced growth-cone collapse. J Neurosci 24, 8994-9004
15483118   Curated Info

5

Gu Y, Hamajima N, Ihara Y (2000) Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522. Biochemistry 39, 4267-75
10757975   Curated Info