Ser172
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Home > Phosphorylation Site Page: > Ser172  -  TBK1 (mouse)

Site Information
EDDEQFVsLYGTEEy   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447732

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 4 , 5 , 8 , 9 ) , phospho-antibody ( 2 , 3 , 7 ) , western blotting ( 2 , 3 , 7 )
Relevant cell line - cell type - tissue:
'neuron, cortical' ( 3 ) , 293 (epithelial) ( 7 ) , brain ( 5 ) , embryo ( 5 ) , liver ( 5 , 8 , 9 ) , MEF (fibroblast) ( 2 ) , stromal ( 4 )

Upstream Regulation
Regulatory protein:
GRN (mouse) ( 3 ) , GSK3B (human) ( 7 ) , IRGM (human) ( 2 )
Treatments:
IFN-gamma ( 2 ) , ischemia ( 4 ) , PGRN ( 3 )

Downstream Regulation
Effects of modification on biological processes:
signaling pathway regulation ( 2 ) , transcription, induced ( 2 )

References 

1

Occhigrossi L, et al. (2021) Transglutaminase 2 Regulates Innate Immunity by Modulating the STING/TBK1/IRF3 Axis. J Immunol 206, 2420-2429
33941660   Curated Info

2

Rai P, et al. (2021) IRGM1 links mitochondrial quality control to autoimmunity. Nat Immunol 22, 312-321
33510463   Curated Info

3

Chang MC, et al. (2017) Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation. J Exp Med 214, 2611-2628
28778989   Curated Info

4

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

5

Stokes MP, et al. (2012) PTMScan Direct: Identification and Quantification of Peptides from Critical Signaling Proteins by Immunoaffinity Enrichment Coupled with LC-MS/MS. Mol Cell Proteomics 11, 187-201
22322096   Curated Info

6

Xie X, et al. (2011) IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation. Proc Natl Acad Sci U S A 108, 6474-9
21464307   Curated Info

7

Lei CQ, et al. (2010) Glycogen synthase kinase 3β regulates IRF3 transcription factor-mediated antiviral response via activation of the kinase TBK1. Immunity 33, 878-89
21145761   Curated Info

8

Zhou J (2009) CST Curation Set: 7446; Year: 2009; Biosample/Treatment: tissue, liver/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]P
Curated Info

9

Zhou J (2009) CST Curation Set: 7447; Year: 2009; Biosample/Treatment: tissue, liver/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: p[ST]P
Curated Info