Lys30
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Home > Ubiquitylation Site Page: > Lys30  -  IKKE (human)

Site Information
VYkARNKkSGELVAV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 40323317

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
breast cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
bortezomib ( 1 ) , IL-1b ( 1 ) , LPS ( 1 ) , MG132 ( 1 ) , TNF ( 1 )

Downstream Regulation
Effects of modification on IKKE:
enzymatic activity, induced ( 1 ) , molecular association, regulation ( 1 ) , phosphorylation ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell growth, induced ( 1 ) , transcription, induced ( 1 )
Induce interaction with:
IKKB (human) ( 1 ) , IKKG (human) ( 1 )

References 

1

Zhou AY, et al. (2013) IKK╬Á-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex. Cell Rep 3, 724-33
23453969   Curated Info