Thr121
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.4
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Thr121  -  TWIST1 (human)

Site Information
NVRERQRtQsLNEAF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 38546302

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:
breast cancer ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
Akt1 (human) ( 2 )
Kinases, in vitro:
Akt1 (human) ( 2 )

Downstream Regulation
Effects of modification on TWIST1:
molecular association, regulation ( 1 ) , protein degradation ( 2 )
Induce interaction with:
TWIST1 (human) ( 1 )

References 

1

Fan X, et al. (2020) TWIST1 Homodimers and Heterodimers Orchestrate Lineage-Specific Differentiation. Mol Cell Biol
32179550   Curated Info

2

Li CW, et al. (2016) AKT1 Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer through Phosphorylation-Dependent Twist1 Degradation. Cancer Res 76, 1451-62
26759241   Curated Info