Ser407

Site Information
QMLsMGFsDEGGWLT SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 40253303

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 4 ) , mass spectrometry ( 2 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 3 ) , phospho-antibody ( 3 , 4 ) , western blotting ( 3 , 4 )
Relevant cell line - cell type - tissue:	'brain, hippocampus' ( 3 ) , E.coli (bacterial) ( 2 ) , HeLa (cervical) ( 4 )

Downstream Regulation
Effects of modification on SQSTM1:	molecular association, regulation ( 1 , 2 )
Effects of modification on biological processes:	autophagy, induced ( 2 , 4 )
Induce interaction with:	ubiquitin (human) ( 1 , 2 )

References
1	Xu L, Zhang Y, Li YM, Lu XF (2020) Total chemical synthesis of the phosphorylated p62 UBA domain reveals that SerPi but not SerPi enhances ubiquitin binding. Org Biomol Chem 18, 8709-8715 33084718 Curated Info
2	Tan XL, et al. (2017) Sortase-mediated chemical protein synthesis reveals the bidentate binding of bisphosphorylated p62 with K63 diubiquitin. Chem Sci 8, 6881-6887 29147513 Curated Info
3	Ha S, et al. (2017) Phosphorylation of p62 by AMP-activated protein kinase mediates autophagic cell death in adult hippocampal neural stem cells. J Biol Chem 292, 13795-13808 28655770 Curated Info
4	Watanabe Y, Tsujimura A, Taguchi K, Tanaka M (2017) HSF1 stress response pathway regulates autophagy receptor SQSTM1/p62-associated proteostasis. Autophagy 13, 133-148 27846364 Curated Info