Lys195
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Home > Ubiquitylation Site Page: > Lys195  -  CFLAR (human)

Site Information
AAIQksLkDPSNNFR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 40245511

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 3 , 4 ) , mutation of modification site ( 5 )
Disease tissue studied:
colorectal cancer ( 5 ) , colorectal carcinoma ( 5 )
Relevant cell line - cell type - tissue:

Downstream Regulation
Effects of modification on CFLAR:
protein degradation ( 5 )
Effects of modification on biological processes:
apoptosis, induced ( 5 )

References 

1

Akimov V, et al. (2018) UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites. Nat Struct Mol Biol 25, 631-640
29967540   Curated Info

2

Morlé A, Garrido C, Micheau O (2015) Hyperthermia restores apoptosis induced by death receptors through aggregation-induced c-FLIP cytosolic depletion. Cell Death Dis 6, e1633
25675293   Curated Info

3

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info

4

Udeshi ND, et al. (2013) Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Mol Cell Proteomics 12, 825-31
23266961   Curated Info

5

Song X, et al. (2013) Hyperthermia enhances mapatumumab-induced apoptotic death through ubiquitin-mediated degradation of cellular FLIP(long) in human colon cancer cells. Cell Death Dis 4, e577
23559011   Curated Info

6

Song X, Kim SY, Lee YJ (2013) Evidence for two modes of synergistic induction of apoptosis by mapatumumab and oxaliplatin in combination with hyperthermia in human colon cancer cells. PLoS One 8, e73654
24013390   Curated Info