Thr176
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Home > Phosphorylation Site Page: > Thr176  -  GATA2 (human)

Site Information
HLFGFPPtPPKEVsP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 40245500

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )

Upstream Regulation
Putative in vivo kinases:
CDK1 (human) ( 1 )
Kinases, in vitro:
CDK1 (human) ( 1 )

Downstream Regulation
Effects of modification on GATA2:
molecular association, regulation ( 1 ) , protein degradation ( 1 )
Induce interaction with:
FBXW7 (human) ( 1 )

References 

1

Nakajima T, et al. (2015) Regulation of GATA-binding protein 2 levels via ubiquitin-dependent degradation by Fbw7: involvement of cyclin B-cyclin-dependent kinase 1-mediated phosphorylation of THR176 in GATA-binding protein 2. J Biol Chem 290, 10368-81
25670854   Curated Info