Ser129
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.7.4
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser129  -  CREB (mouse)

Site Information
kILNDLssDAPGVPR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448548

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 4 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 , 4 ) , phospho-antibody ( 3 , 4 ) , western blotting ( 1 , 3 )
Disease tissue studied:
liver cancer ( 1 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 3 ) , 'brain, visual cortex' ( 4 ) , 'neuron, cortical'-brain ( 4 ) , brain ( 2 ) , HepG2 (hepatic) ( 1 )

Upstream Regulation
Treatments:
KCl ( 4 ) , visual experience ( 3 )

Downstream Regulation
Effects of modification on biological processes:
neural plasticity ( 4 ) , transcription, induced ( 4 )

References 

1

Sheng L, et al. (2012) NF-κB–inducing kinase (NIK) promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon action. Nat Med 18, 943-9
22581287   Curated Info

2

Wiśniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9
20415495   Curated Info

3

Suzuki S, al-Noori S, Butt SA, Pham TA (2004) Regulation of the CREB signaling cascade in the visual cortex by visual experience and neuronal activity. J Comp Neurol 479, 70-83
15389611   Curated Info

4

Pulimood NS, et al. Phosphorylation of CREB at Serine 142 and 143 Is Essential for Visual Cortex Plasticity. eNeuro 8
34607805   Curated Info