Ser44
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Home > Phosphorylation Site Page: > Ser44  -  K17 (mouse)

Site Information
AGsCRLGsASGLGSA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 464291

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
308 (keratinocyte) ( 1 ) , BHK (fibroblast) ( 2 )

Upstream Regulation
Regulatory protein:
PKCA (mouse) ( 1 )
Putative in vivo kinases:
p90RSK (mouse) ( 1 )
Kinases, in vitro:
p90RSK (human) ( 1 )
Treatments:
EGF ( 1 ) , Go_6976 ( 1 ) , okadaic_acid ( 1 ) , phorbol_ester ( 1 ) , SB203580 ( 1 ) , serum ( 1 ) , sorbitol ( 1 ) , SP600125 ( 1 ) , U0126 ( 1 ) , UV ( 1 )

Downstream Regulation
Effects of modification on K17:
molecular association, regulation ( 2 )
Effects of modification on biological processes:
cell cycle regulation ( 2 )

References 

1

Pan X, Kane LA, Van Eyk JE, Coulombe PA (2011) Type I keratin 17 protein is phosphorylated on serine 44 by p90 ribosomal protein S6 kinase 1 (RSK1) in a growth- and stress-dependent fashion. J Biol Chem 286, 42403-13
22006917   Curated Info

2

Kim S, Wong P, Coulombe PA (2006) A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth. Nature 441, 362-5
16710422   Curated Info

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