Ser128
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Home > Phosphorylation Site Page: > Ser128  -  CREB (mouse)

Site Information
RkILNDLssDAPGVP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448547

In vivo Characterization
Methods used to characterize site in vivo:
[32P] ATP in vitro ( 3 ) , immunoassay ( 10 ) , mass spectrometry ( 2 , 3 , 4 , 5 , 6 , 7 ) , mutation of modification site ( 3 , 9 , 10 ) , phospho-antibody ( 8 , 9 , 10 ) , western blotting ( 3 , 8 , 9 )
Disease tissue studied:
anthrax infection ( 4 ) , liver cancer ( 3 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 8 , 9 ) , 'brain, hippocampus' ( 9 ) , 'brain, hypothalamus, suprachiasmatic nucleus' ( 9 ) , 'brain, visual cortex' ( 10 ) , 'neuron, cortical'-brain ( 10 ) , 32Dcl3 (myeloid) [FLT3 (mouse), transfection, chimera with human FLT3-ITD mutant (corresponding to wild type P36888 ( 7 ) , brain ( 2 , 5 , 6 ) , hepatocyte-liver ( 3 ) , HepG2 (hepatic) ( 3 ) , lung ( 5 ) , spleen ( 4 , 5 )

Upstream Regulation
Kinases, in vitro:
Nik (human) ( 3 )
Treatments:
glutamic acid ( 9 ) , K252a ( 8 ) , KCl ( 10 ) , light ( 9 ) , MK801 ( 8 ) , TTX ( 8 ) , visual experience ( 8 )

Downstream Regulation
Effects of modification on CREB:
activity, induced ( 9 )
Effects of modification on biological processes:
neural plasticity ( 10 ) , transcription, altered ( 9 ) , transcription, induced ( 10 )

References 

1

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

2

Goswami T, et al. (2012) Comparative phosphoproteomic analysis of neonatal and adult murine brain. Proteomics 12, 2185-9
22807455   Curated Info

3

Sheng L, et al. (2012) NF-κB–inducing kinase (NIK) promotes hyperglycemia and glucose intolerance in obesity by augmenting glucagon action. Nat Med 18, 943-9
22581287   Curated Info

4

Manes NP, et al. (2011) Discovery of mouse spleen signaling responses to anthrax using label-free quantitative phosphoproteomics via mass spectrometry. Mol Cell Proteomics 10, M110.000927
21189417   Curated Info

5

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

6

Wiśniewski JR, et al. (2010) Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology. J Proteome Res 9, 3280-9
20415495   Curated Info

7

Choudhary C, et al. (2009) Mislocalized activation of oncogenic RTKs switches downstream signaling outcomes. Mol Cell 36, 326-39
19854140   Curated Info

8

Suzuki S, al-Noori S, Butt SA, Pham TA (2004) Regulation of the CREB signaling cascade in the visual cortex by visual experience and neuronal activity. J Comp Neurol 479, 70-83
15389611   Curated Info

9

Gau D, et al. (2002) Phosphorylation of CREB Ser142 regulates light-induced phase shifts of the circadian clock. Neuron 34, 245-53
11970866   Curated Info

10

Pulimood NS, et al. Phosphorylation of CREB at Serine 142 and 143 Is Essential for Visual Cortex Plasticity. eNeuro 8
34607805   Curated Info